A method for isolating, from a biological sample derived from a member of a mammalian species, a lymphocyte specific for an antigen of an organism capable of infecting that species; the sample also contains lymphocytes not specific for the antigen, and the method involves contacting the lymphocytes of the sample with the antigen and selecting a lymphocyte which proliferates in response to the antigen, the selected lymphocyte being the desired antigen-specific lymphocyte.
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