Benzimidazole derivatives, their preparation and their application as medicaments

摘要

The invention relates to new compounds derived from benzimidazole, characterised in that they correspond to the general formula I, and to their therapeutically acceptable salts, …IMAGE… in which: … …  - R1 and R2, which may be the same or different, represent a hydrogen atom, a halogen, a lower alkyl radical, a hydroxyl radical, an alkoxy radical, an alkyl carboxylate radical, an aryl or substituted aryl radical, …  - n can have the values 0 or 1, …  - m can have the values 2 to 4, …  - X, Y, Z and W, which may be the same or different, and even forming part of another aromatic or non-aromatic ring, represent a nitrogen atom or a carbon atom linked to a hydrogen atom, a halogen or to another alkyl, aryl, carboxyalkyl, carboxyl, hydroxyl, alkylhydroxy, sulphonic and alkylsulphonic radical. … …??The invention also relates to the process for preparing the compounds and to their use for the manufacture of medicaments intended for the prophylaxis and treatment of various histamine-induced allergic diseases.