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6- (6-SUBSTITUTED-TRIAZOLOPYRIDAZINE-SULFANYL) DERIVATIVES 5-FLUORO-BENZOTHIAZOLES AND 5-FLUORO-BENZIMIDAZOLES: PREPARATION, APPLICATION AS MEDICAMENTS AND USE AS INHIBITORS OF MET.
6- (6-SUBSTITUTED-TRIAZOLOPYRIDAZINE-SULFANYL) DERIVATIVES 5-FLUORO-BENZOTHIAZOLES AND 5-FLUORO-BENZIMIDAZOLES: PREPARATION, APPLICATION AS MEDICAMENTS AND USE AS INHIBITORS OF MET.
The invention relates to novel products of the formula (I) where: (II) is a single or double bond; F is a fluorine atom, Ra is H, HaI, alkoxy, O-cycloalkyl, O heterocycloalkyl; NH-heterocycloalkyl, heteroaryl, phenyl, NHCOalk NHCOcycloalk or NR1 R2; X is S, SO or SO2, A is NH or S; W is H, alkyl, or COR with R being cycloalkyl; alkyl optionally substituted by NR3R4, alkoxy, hydroxy, phenyl, heteroaryl or heterocycloalkyl; alkoxy optionally substituted by NR3R4, i.e. a O(CH2)n-NR3R4 radical, an O-phenyl or an O(CH2)n-phenyl radical, with phenyl optionally substituted and n=1 to 4; or the NR1 R2 radical; R1 is H or alk and R2 is H, cycloalkyl or alkyl; R3 and R4 are H, alk, cycloalkyl, heteroaryl or phenyl; R1, R2 and/or R3, R4 form a cycle together with N optionally containing O, S, N and/or NH; heterocycloalkyl, heteroaryl and phenyl and cycles all being optionally substituted; wherein said products can be in any isomer or salt form, and can be used as drugs, in particular as MET inhibitors.
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机译:本发明涉及式(I)的新产物,其中:(II)是单键或双键; F是氟原子,Ra是H,Hal,烷氧基,O-环烷基,O杂环烷基; NH-杂环烷基,杂芳基,苯基,NHCOalk NHCO环烷基或NR1 R2; X为S,SO或SO 2,A为NH或S; W为H,烷基或COR,R为环烷基;任选地被NR 3 R 4取代的烷基,烷氧基,羟基,苯基,杂芳基或杂环烷基;任选地被NR 3 R 4取代的烷氧基,即O(CH 2)n -NR 3 R 4基,O-苯基或O(CH 2)n苯基,其中苯基任选地被取代且n = 1至4;或NR1 R2基团; R1是H或烷基,R2是H,环烷基或烷基; R3和R4为H,烷基,环烷基,杂芳基或苯基; R 1,R 2和/或R 3,R 4与任选地包含O,S,N和/或NH的N一起形成一个环;杂环烷基,杂芳基和苯基以及环均被任选取代;其中所述产物可以是任何异构体或盐形式,并且可以用作药物,特别是用作MET抑制剂。
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