A hand-held cryofixation apparatus in the form of a pistol handgrip into which is mounted a pneumatic cylinder and piston rod. A removable adapter and tissue mount is attached to the end of said piston rod. The handgrip is further fashioned with a slot or cutout into which is slidably disposed an L-shaped metal rod, the upturned leg of which supports a mirror finish metal block. Upon activation of the pneumatic cylinder the tissue mount is slammed against the mirror finish metal block which has been precooled by immersion into a cryogen such as liquid nitrogen or helium.
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