Process for stereoselectively hydrolyzing, transesterifying or esterifying with immobilized isozyme of lipase from Candida rugosa

摘要

Process for stereoselectively hydrolyzing esters or esterifying acids with lipase preparations of Candida rugosa in aqueous/organic systems, where the acid is not substituted at the 2-position with a halogen, e.g. process for the production of R-2-(4-hydroxyphenoxy)propionic acid at high en tiomeric excess. Additionally disclosed is a process for separating and purifying the isozymes from the lipase of Candida rugosa and their use for the stereoselective hydrolysis of esters, transesterification of esters and esterification of acids.