SERIES OF ARECOLINE AND NICOTINE-ORIENTED ACTIVITY OF ISOARECOLINE

摘要

PURPOSE: To obtain a pharmaceutical preparation containing arecolone and isoaecolone and used for treatment of Alzheimer's disease, the other central nervous system-related diseases, pain, gastroenteric diseases and diabetes mellitus. CONSTITUTION: This pharmaceutical preparation comprises a compound of formula I or formula II (R is a 2-6C alkyl, a 2-6C alkenyl, a 2-6C alkinyl, a 2-6C alkoxyalkyl, a 2-6C alkylthioalkyl, a 2-6C alkylaminoalkyl, a 3-6C cycloalkyl or a 1-6C alkyl substituted with 3-6C cycloalkyl or a 1-6C polyfluoroalkyl; R1 is H or 1 or 2 1-3C alkyl) or its physiologically active acid addition salt, e.g. 1-(1,2,5,6-tetrahydro-1-methyl-3-pydinyl)-1-propanone hydrochloride as an active ingredient. The compound has cholinergic nicotinic activity and has selective affinity for nicotinic receptor.