EMULSION OF THE TYPE OF OIL IN WATER OF AN X-RAY CONTRAST AGENT BASED ON IODATE ORGANIC COMPOUNDS, ESTERIZABLE BY HEAT ACTION, ADMINISTRATION BY PARENTERIC VIA, AND PROCESS FOR THEIR PREPARATION

摘要

The invention relates to a parenterally administrable, heat-sterilisable O/W emulsion of an X-ray contrast agent with an inner phase of one or more suitable oil-soluble organic iodine compounds, especially iodised fatty acid esters, one or more emulsifiers and, where appropriate, co-emulsifiers and an outer phase of distilled water with isotonising additives, characterised by a content of a physiologically acceptable buffer of caustic soda and one or more suitable inorganic and/or organic phosphates. The emulsions obtained are distinguished by good shelf life and heat stability and can therefore be sterilised in autoclaves at 121C.