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Oil-in-water emulsion of a contrasting agent of drains X based on iodized organic compounds, sterilizable by the action of heat and administrable via parenteral, and process for its preparation
Oil-in-water emulsion of a contrasting agent of drains X based on iodized organic compounds, sterilizable by the action of heat and administrable via parenteral, and process for its preparation
The invention relates to a parenterally administrable, heat-sterilisable O/W emulsion of an X-ray contrast agent with an inner phase of one or more suitable oil-soluble organic iodine compounds, especially iodised fatty acid esters, one or more emulsifiers and, where appropriate, co-emulsifiers and an outer phase of distilled water with isotonising additives, characterised by a content of a physiologically acceptable buffer of caustic soda and one or more suitable inorganic and/or organic phosphates. The emulsions obtained are distinguished by good shelf life and heat stability and can therefore be sterilised in autoclaves at 121C.
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