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PARENTERALLY APPLICABLE, HEAT STABILIZED EMULSION OF THE OIL-IN-WATER EMULSION TYPE OF X-RAY CONTRAST AGENT
PARENTERALLY APPLICABLE, HEAT STABILIZED EMULSION OF THE OIL-IN-WATER EMULSION TYPE OF X-RAY CONTRAST AGENT
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机译:并行适用的X射线造影剂水包油型乳液的热稳定乳液
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摘要
The invention relates to a parenterally administrable, heat-sterilisable O/W emulsion of an X-ray contrast agent with an inner phase of one or more suitable oil-soluble organic iodine compounds, especially iodised fatty acid esters, one or more emulsifiers and, where appropriate, co-emulsifiers and an outer phase of distilled water with isotonising additives, characterised by a content of a physiologically acceptable buffer of caustic soda and one or more suitable inorganic and/or organic phosphates. The emulsions obtained are distinguished by good shelf life and heat stability and can therefore be sterilised in autoclaves at 121C.
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