11-METHYLENE-OESTR-15-ENES, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS

摘要

ABSTRACTThe present invention is concerned with novel 11-methylene-oestr-15-enes of the formula: (formula I)whereinR1 = H or acyl with 1-18 C-atoms, preferably H,R2 = ethinyl, vinyl, chloroethinyl, allyl or propinyl; ethinyl beingpreferred, andR3 = O or H2, preferably O.further the present invention is concerned with processes for thepreparation of the above compounds and with pharmaceuticalcompositions comprising these compounds. The compounds possesspowerful gestagenic properties and only slight androgenic side-effects.