PROCESS FOR THE PREPARATION OF CINNAMOYL-13ALPHA BACCATIN III OR DESACETYL-10 BACCATIN III.

摘要

Process for the preparation of 13 alpha -cinnamoylbaccatin III or 13 alpha -cinnamoyl-10-deacetylbaccatin III of formula (I) by condensation of a mixed anhydride of general formula (II) with a derivative of baccatin III or of 10-deacetylbaccatin III of general formula (III). In the formulae (I) and (III), R1 represents an acetyl or 2,2,2-trichloroethoxycarbonyl radical. In the formula (II), R represents 1 to 5 substituents, which are identical or different (halogen, nitro, methyl or methoxy). IMAGE