Process for the preparation of baccatin III derivatives and of desacetyl-10 baccatin III

摘要

Process for preparing derivatives of baccatine III and of 10-deacetylbaccatine III, of general formula (I), in which R is hydrogen or acetyl, by condensation of an acid of general formula (II) with a derivative of baccatine III or of 10-deacetylbaccatine III of general formula (III), R1, R2 and R3 denoting hydroxy-protecting groups, followed by the replacement of the protecting groups by hydrogen. IMAGE (I) IMAGE (III) IMAGE (IV)