METHOD FOR OXIDIZING HYDROXYMETHYLPYRIDINE DERIVATIVE TO PYRIDINE CARBOXYLIC ACID DERIVATIVE

摘要

PURPOSE: To obtain a corresponding pyridine carboxylic acid simply and in excellent yield by electrochemically oxidizing a hydroxymethylpyridine deriv. of a specific structural formula at NiO(OH) anode. ;CONSTITUTION: The hydroxymethylpyridine deriv. having a structural formula expressed by formula I is electrochemically oxidized at the NiO(OH) anode. In formula I, X denotes H, 1-12C alkyl, 6-12C allyl, COOR¹, CONH₂, CONHR¹, CON(R¹)₂, CN, C(O)R¹, SO₂R¹, SO₃H and NO₂ and R¹ denotes H, 1-12C alkyl and 6-12C allyl. By this method, o-hydroxymethylpyridine deriv. can be selectively oxidized to the corresponding pyridine carboxylic acid deriv. (compound of formula II). The method can be technically simply executed and the necessary products can be produced in excellent yield.;COPYRIGHT: (C)1993,JPO