Bis (alkylsulfonylamino) substituted alkyl (heterocyclyl) phenethylamine compounds, pharmaceutical compositions containing them, the compounds for use as pharmaceuticals, the use of the compounds for the manufacture of medicaments for the prevention or reduction of cardiac arrhythmias and alkyl (heterocyclyl) phenethylamine compounds for use as intermediates

摘要

Compounds of the formula:- CHEM and their salts, where R is -NHSO2(C1-C4 alkyl), -NH2 or -NO2; R1 is C1-C4 alkyl; and "Het" is a group of the formula:- CHEM where R2 is H, CH3 or C2H5; R3 is -NHSO2(C1-C4 alkyl), -NH2 or -NO2; and X is O, S or NR4 where R4 is H or CH3; with the proviso that when one of R and R3 is -NO2, then the other is not -NH2. The compounds of the formula (A) in which both R and R3 are -NHSO2(C1-C4 alkyl) are antiarrhythmic agents. The reamining compounds of the formula (A) are synthetic intermediates.