alkyl (heterocyclymethyl) phenethylamine compoundspharmaceutical preparations containing the alkylsulfonylaminosubstituerede compounds and use of these for the manufacture of a medicinal product for the prevention or reduction of cardiac arrhythmias

摘要

Compounds of the formula:- CHEM and their salts, where R is -NHSO2(C1-C4 alkyl), -NH2 or -NO2; R1 is C1-C4 alkyl; and "Het" is a group of the formula:- CHEM where R2 is H, CH3 or C2H5; R3 is -NHSO2(C1-C4 alkyl), -NH2 or -NO2; and X is O, S or NR4 where R4 is H or CH3; with the proviso that when one of R and R3 is -NO2, then the other is not -NH2. The compounds of the formula (A) in which both R and R3 are -NHSO2(C1-C4 alkyl) are antiarrhythmic agents. The reamining compounds of the formula (A) are synthetic intermediates.