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CHIMAERIC PROTEIN CONTAINING MODIFIED SEQUENCE OF COAT PROTEIN OF PHAGE MS-2, CAPSIDS, VECTORS AND VACCINES CONTAINING IT
CHIMAERIC PROTEIN CONTAINING MODIFIED SEQUENCE OF COAT PROTEIN OF PHAGE MS-2, CAPSIDS, VECTORS AND VACCINES CONTAINING IT
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机译:包含修饰的噬菌体蛋白蛋白序列的MS-2衣壳蛋白序列,衣壳,载体和疫苗
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PCT No. PCT/GB92/01159 Sec. 371 Date Jan. 3, 1995 Sec. 102(e) Date Jan. 3, 1995 PCT Filed Jun. 26, 1992 PCT Pub. No. WO93/00434 PCT Pub. Date Jan. 7, 1993A chimaeric protein is provided, capable of forming part of a capsid assembly and comprising the amino acid sequence of the coat protein of phage MS-2, or a conservatively modified variant thereof, or sufficient of said sequence or variant to retain the capability of forming a capsid assembly, which amino acid sequence has been modified by removal of the cysteine residues present externally of the N-terminal protruberant beta -hairpin of the coat protein and insertion of a cysteine residue within the region corresponding to the N-terminal protruberant beta -hairpin.
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