6,8 DIOXABICYCLO3.2.1OCTANES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS

摘要

Compounds having the formula I: (see fig.I) are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, antiallergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis and allograft rejection and in preventing the formation of atherosclerotic plaques.