The present invention provides isolated peptides of Japanese cedar pollen protein allergen, Cry jI. The fetid in the context of the present invention comprises at least one T cell epitope of Cry jI, or preferably at least two T cell epitopes. The invention also relates to modified proteins having similar or improved therapeutic properties to the corresponding natural allergens or portions thereof, but with reduced side effects. The present invention further provides nucleic acid sequences encoding the peptides of the present invention. In the individual, therapeutic or diagnostic methods of sensitivity to Japanese cedar pollen and therapeutic compositions comprising one or more peptides of the invention are also provided. The present invention also provides nucleic acid sequences encoding Jun s I and Jun v I allergens and Jun v I and Jun s I protein allergens. Jun sI and Jun vI are protein allergens that are immunologically cross reactive with Cry jI.
机译：本发明提供了日本雪松花粉蛋白变应原Cry jI的分离的肽。在本发明的上下文中，该胎儿包括Cry jI的至少一个T细胞表位，或优选地至少两个T细胞表位。本发明还涉及与相应的天然变应原或其部分具有相似或改善的治疗性质但具有减少的副作用的修饰的蛋白质。本发明进一步提供了编码本发明的肽的核酸序列。在个体中，还提供了对日本柳杉花粉敏感的治疗或诊断方法以及包含一种或多种本发明肽的治疗组合物。本发明还提供了编码Jun s I和Jun v I过敏原以及Jun v I和Jun s I蛋白过敏原的核酸序列。 Jun sI和Jun vI是与Cry jI发生免疫交叉反应的蛋白质过敏原。