METHOD OF SYNTHESIS OF 10-METHOXY -5- METHYL-6- (1',1'- DIOXIDO-2' -METACHLOROPHENYLAZO -3'- HYDROXY -4'-METHOXYBENZOB THIOPHENE -7-YL) -5H- 3,4,6,7-TETRA- HYDROFURO4,3,2-Q 3BENZAZOCINE

摘要

FIELD: organic chemistry. SUBSTANCE: product - 10-methoxy -5- methyl-6 -(1,1 -dioxido- 2-meta-chlorophenylazo -3- hydroxy -4'- methoxybenzo[b] thiophene-7-yl)-5H-3,4,6,7-tetr - ahydrofuro [4,3,2-Q][3] benzazocine, empirical formula is C₁₉H₂₆ClN₃O₆, yield is 80%, m. p. is 205-208 C. Reagent 1: 10-methoxy -6- (4-methoxy -1, 1, 3- trioxo-2, 3-dihydrobenzothienyl - 7) -5-methyl -3,4,6,7- tetrahydro-5H- furo[4,3,2-Q][3]benzazoci- ne. Reagent 2: diazonium salt prepared from meta-aniline and sodium nitrite in aqueuos HCl. Reaction conditions: azo coupling reaction in the mixture of pyridine and water at 5 C firstly and then at the room temperature. Synthesized compound is used in medicine. EFFECT: improved method of synthesis. 4 tbl