METHOD OF SYNTHESIS OF 2,6-DI-TERT-BUTYL-4-(3-HYDROXYPROPYL)-PHENOL

摘要

FIELD: organic chemistry. SUBSTANCE: 2,6-di-tert. -butyl-4-(3-hydroxypropyl)-phenol is synthesized by alkylation of 2,6-di-tert.-butylphenol with allyl alcohol at increased temperature and pressure, at mole ratio phenol:alcohol = 1:(1.2-2.0) for 3.5-4 h. The end product is separated from the vat residue by vacuum distillation. Catalyst: vat residue of distillation containing 3-(3.5-di-tert.-butyl-4-hydroxyphenyl)-propanol-1 sodium salt which is prepared preliminary by interaction of 2,6-di-tert.-butylphenol with sodium hydroxide at stirring and heating from 110 to 145 C with simultaneous distillation of water formed. Then mixture is cooled, mixed with allyl alcohol, and reaction is carried out for 3.5 h. Reaction mass is distilled under vacuum, and prepared vat residue is mixed with the parent reagents at the mass ratio phenol:vat residue = 3.85:1. After 3-4 reaction cycles all reactions beginning from catalyst preparing were repeated. Alkylated phenols were used in organic synthesis. EFFECT: improved method of synthesis.