One Step procedure for the manufacture of 3 - quinoloncarboxilico acid derivatives

摘要

Understand: 1) characterized by reacting an Acid Halide formula XXVI where Hal, x2 and X3 are f or CL, with: (a) a dimetilaminoacrilico acid ester of formula (CH3) 2n - ch = CH - coor,Followed by the addition of an Amine R1 - NH2; or (b) a aminoacrilester formula r1nh - ch = CH - coor; R is Methyl, Ethyl or propyl; 2) Heat (1) at a temperature of 60 degrees to 100 degrees.In a Solvent such as n-methyl pyrrolidone with POTASSIUM CARBONATE as an Auxiliary base, forming a nitrogen cycle; 3) reacting a Heterocyclic Compound with (2) ` r "N, rForming a compound of formula I, where r, R 'n Form "together with a Monkey or bicyclic heterocycle; is CH, CF, CCL, C - C - OCH3, CH3; x1 is H, halogen, CH3, NH2, R1 is alkyl fch2ch2 C1 - C3 -Ciclopropilo can be replaced by one to three halogens; which is useful as antibacterial