PROCESS FOR THE PREPARATION OF (20R)-16 ALPHA,17 ALPHA -BUTYLIDENEDIOXY-6 ALPHA,9 ALPHA-DIFLUORO-11 BETA-HYDROXY 17 BETA-(METHYLTHIO) ANDROST-4-3-ONE

摘要

A process is described for the preparation of (20R)-16α,17α-butylidenedioxy-6α,9α-difluoro-11β-hydroxy-17β-(methylthio)androst-4-en-3-one comprising a six step synthesis from a compound of formula (I). (20R)-16α,17α-Butylidenedioxy-6α,9α-difluoro-11β-hydroxy-17β-(methylthio) androst-4-en-3-one is a pharmacologically active steroid which possesses anti-inflammatory, immunosuppressive and anti-allergic activity.