Percutaneous instruments with natural tissue adhesive non-infective treatment on the surface of transdermal instruments and methods of manufacturing the same

摘要

The present invention relates to a transdermal device obtained by treating the surface of the transdermal device without infection with a natural tissue adhesive disease, and to a method of manufacturing the same. The surface of the transdermal device made of a conventional polymer material is coated with a collagen antimicrobial composite, dried and sterilized. To provide a natural tissue adhesion non-infected transdermal device.;According to the present invention, the natural tissue-adhesive non-infected transdermal device treated with collagen-antimicrobial composite prepared by adding an antimicrobial agent to collagen is gradually degraded by collagenase (chllagenase) after being inserted into the body. Release to prevent and prevent infection, replaced by regenerating epithelial tissue by a healing process, and antimicrobial agents incorporated into the collagen matrix are released until the space is completely blocked by regenerating epithelial tissue and prevent infection And prevention.