METHOD OF SYNTHESIS OF DES-GLY¹amp;hairsp;⁰, (D-LEU⁶)-LH-RH-ETHYLAMIDE

摘要

FIELD: organic chemistry, peptides. SUBSTANCE: synthesis is carried out by condensation of amino acid derivatives by method of series-parallel peptide chain splicing according the scheme given in description text. Method uses an arginine which is unprotected by guanidine group, synthesis of fragments 1-2 and 3-4 with unprotected C-terminal carboxylic functions. EFFECT: preparative peptide synthesis of luliberin analogs in solution.