Bifunctional chalcogen atom-interrupted chelating agents of the type S¶3¶N¶2¶ for radioactive isotopes and their metal complexes, processes for their preparation and pharmaceutical compositions containing them

摘要

PCT No. PCT/DE94/00370 Sec. 371 Date Mar. 8, 1996 Sec. 102(e) Date Mar. 8, 1996 PCT Filed Mar. 29, 1994 PCT Pub. No. WO94/22492 PCT Pub. Date Oct. 13, 1994This invention relates to new bifunctional chelating agents with intermittent chalcogen atoms, pharmaceuticals containing these compounds, their use in radiodiagnostics and radiotherapy, and methods for the production of these compounds. The compound according to the invention has the general formula (I) M-L wherein M represents a radionuclide of Tc or Re and L a ligand of the general formula (II) B-CO-CR1R2-A-CR3R4-CO-D(II) These new, bifunctional chelating agents with intermittent chalcogen atoms and their coupling products with compounds that accumulate specifically are suited for producing radiopharmaceuticals for diagnostic and therapeutic purposes.