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Metal chelates as anti-cancer agents. II cytotoxic action of palladium and platinum complexes of 6-mercaptopurine and thioguanine.

机译：金属螯合物作为抗癌剂。 II-6-巯基嘌呤和硫鸟嘌呤的钯和铂配合物的细胞毒性作用。

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The metal complexes Pd(MP)2.2H2O, Pt(MP)2H2O (MPH=6-mercaptopurine), Pt(AMP2.3H2O and Pd3(AMP)4Cl2(AMPH).4H2O (AMPH=thioguanine) have been isolated. They were screened for anti-tumour activity in the L-1210 lymphoid leukaemia test system in mice. All 4 show marked anti-tumour activity, the complex Pt(AMP)2.3H2O giving a T/C of 185 at the optimum dosage. However, the anti-tumour activity of the metal complexes is somewhat less than that shown by the parent purines under the same conditions.

机译：分离出金属配合物Pd（MP）2.2H2O，Pt（MP）2H2O（MPH = 6-巯基嘌呤），Pt（AMP2.3H2O和Pd3（AMP）4Cl2（AMPH）.4H2O（AMPH =硫代鸟嘌呤）。在小鼠L-1210淋巴白血病试验系统中筛选了抗肿瘤活性，所有4种化合物均显示出显着的抗肿瘤活性，复合Pt（AMP）2.3H2O在最佳剂量下的T / C为185。在相同条件下，金属配合物的抗肿瘤活性略低于母嘌呤。

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期刊名称 British Journal of Cancer
作者
M. Das; S. E. Livingstone;
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作者单位

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年(卷),期 1978(38),2
年度 1978
页码 325–328
总页数 4
原文格式 PDF
正文语种
中图分类肿瘤学;
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入库时间 2022-08-17 13:49:39

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1. Metal chelates as anti-cancer agents. II cytotoxic action of palladium and platinum complexes of 6-mercaptopurine and thioguanine [J] . M Das, S E Livingstone British Journal of Cancer . 1978,第2期

机译：金属螯合物作为抗癌剂。 II-6-巯基嘌呤和硫代鸟嘌呤的钯和铂配合物的II细胞毒性作用
2. Synthesis and characterization of palladium(II) and platinum(II) metal complexes with iminophosphine ligands: X-ray crystal structures of platinum(II) complexes and use of palladium(II) complexes as pre-catalysts in Heck and Suzuki cross-coupling reactions [J] . Haleden Chiririwa, Freeman Ntuli, Edison Muzenda Transition Metal Chemistry . 2013,第4期

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3. Mononuclear platinum(II) and palladium(II) dithiolate complexes as chelate metalloligands for preparation of heterobimetallic d(8)-d(8) complexes [J] . Fornies-Camer J., Claver C., Cardin CJ., Inorganic Chemistry: A Research Journal that Includes Bioinorganic, Catalytic, Organometallic, Solid-State, and Synthetic Chemistry and Reaction Dynamics . 1998,第11期

机译：单核铂（II）和钯（II）二硫醇盐配合物，用作螯合金属配体，用于制备杂双金属d（8）-d（8）配合物
4. Preparation and Properties of Chelate Complexes of Tungsten(O)and Platinum(II) Ligated by Bulky 3-Thioxo-l,3-diphosphapropenes [C] . Shigekazu Ito, Hongze Liang, Masaaki Yoshifuji Symposium on Organometallic Chemistry . 2003

机译：铜酸盐配合物的制备与甘氨酸（II）通过庞大的3-硫代氧-1，3-二磷丙酮连接的铂（II）
5. Metallophilic interactions between coordinatively unsaturated complexes of rhodium(I), iridium(I), palladium(II), platinum(II) and gold(I) [D] . Gussenhoven, Emily M. 2008

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6. Synthesis Characterization and In Vitro Cytotoxic Activities of Benzaldehyde Thiosemicarbazone Derivatives and Their Palladium (II) and Platinum (II) Complexes against Various Human Tumor Cell Lines [O] . Wilfredo Hernándeza, Juan Paz, Abraham Vaisberg, 2008

机译：苯甲醛硫杂氨基脲类衍生物及其钯（II）和铂（II）配合物对各种人类肿瘤细胞系的合成表征和体外细胞毒活性
7. Metal chelates as anti-cancer agents. II cytotoxic action of palladium and platinum complexes of 6-mercaptopurine and thioguanine. [O] . Das, M., Livingstone, S. E. 1978

机译：金属螯合物作为抗癌剂。 II-6-巯基嘌呤和硫鸟嘌呤的钯和铂配合物的细胞毒性作用。
8. Metallaborane Chemistry. Part 1. Oxidative-Insertion Reactions of Dicarbaundecaborane and Metalladicarbaundecaborane Species with Zerovalent Nickel, Palladium, and Platinum Complexes. [R] . Green, M., Spencer, J. L., Stone, E. G. A., 1974

机译：金属硼烷化学。第1部分：二十烷癸烷和metalladicarbaundecaborane物种与零价镍，钯和铂配合物的氧化插入反应。

Metal chelates as anti-cancer agents. II cytotoxic action of palladium and platinum complexes of 6-mercaptopurine and thioguanine.

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