Naphthalenylmethyl cycloalkenone acetic acids and analogs thereof useful as aldose reductase inhibitors

摘要

The compounds of this invention which have the formula: ##STR1## wherein: R.sup.1 and R.sup.2 are independently hydrogen, C.sub.1 -C.sub.8 alkyl, halogen, C.sub.1 -C.sub.8 alkoxy, or trifluoromethyl; P PR.sup.3 is --OH or --NHCO.sub.2 CH.sub.3 ;P PX is -- CH.sub.2 -- or --OCH.sub.2 --;PPn is 1 or 2; P Por a pharmaceutically acceptable salt thereof,P Pare useful in treating or inhibiting the long-term complications of diabetes such as diabetic retinopathy, nephropathy and neuropathy through the inhibition of the enzyme aldose reductase. Aldose reductase inhibitors have been shown to prevent the biochemical, functional and morphological changes induced by hyperglycemia.