Structural-Based Inhibitors of the Glutathione Binding Site in Aldose Reductase, Methods of Screening Therefor and Methods of Use.

摘要

Provided herein is a crystallized ternary structure of aldose reductase (AR) bound to NADPH and gamma-glutamyl- S-(1,2-dicarboxyethyl) cysteinylglycine (DCEG). Also provided are specific inhibitors of glutathione-aldehyde binding to aldose reductase which are designed via at least computer modeling of the ternary AR:NADPH:DCEG structure and methods of designing and of screening the inhibitors for inhibition of glutathione-aldehyde binding to aldose reductase.