Ether lipid-nucleoside covalent conjugates

摘要

Ether lipid nucleoli covalent conjugates and derivatives thereof are disclosed, along with pharmaceutical compositions containing the same and methods of using the same to combat HIV-1 infections. Illustrative are 3'- Azido-3'-deoxythmidine-5'-monophosphate-D,L-3- octadecanamido-2-ethoxypro pane and 3'-Azido-3'-deoxythymidine-5'- butyrate-&ggr;-N,N,N-trimethyl - ammonium-&bgr;-(1-phospho-2-ethoxy-3- hexadecyloxypropane).