Lighten bitterness the solid preparation and its production manner

摘要

PURPOSE:To obtain a bitter drug-containing solid agent having extremely reduced bitterness and a mallow feeling in the mouth, by blending a bitter drug with calcium silicate. CONSTITUTION:A bitter drug such as vitamin B1, B2, B6, calcium pantothenate, nicotinic acid amide, other hydrochloride and sulfate is blended with calcium silicate and dried to give the aimed substance. The weight ratio of the calcium silicate to the bitter drug is preferably =1. The aimed substance may be prepared into a solid agent such as tablet, granule fine granule and powder. The calcium silicate is porous powder and calcium silicate of furolite of trade name has extremely large bulk, large oil absorption amount, is safe and preferable.