The chemotherapy of asymmetric ligand neutron therapy disease and tumour

摘要

The present invention is to be related to the whereA asymmetric ligands of general formula I, M is hydrogen or tert-butyl, and D is hydrogen-CH2-Ar, and Ar is the aryl with 6 carbon atoms, there can be 1-9 carbon atom with alkyl one or disubstituted, or structure OCH2 (CH2OCH2) nCH2-O-Z, wheren of 2-thienyl, X are numbers 0,1,2, Z is hydrogen, alkyl C1arrives C6, benzyl or B groups (OH) 2, and wherein B is atomic boron. The racemic or chipal compounds of asymmetric ligand. To be based on known facts be alcohol benzyl keys in acid medium the is easy ionization of its method prepared is reacted with the cationic nucleophilic reagent of above-mentioned origin. In the case where us, from the alcohol (two) being easily accessible in Formula II, M has above-mentioned definition, and T is hydrogen or group-CH2OH. The general formula II reactions of derivative be easy to aromatics and miscellaneous material rich in electronics and in acid condition, they provide the product of general formula IIIs, and here, M, D, Ar are with above-mentioned meaning. These compounds are interesting ligands, furthermore, it is possible to be converted into seeking I. by well known methodThe compound ofIMAGEgeneral formula