THE INVENTION DESCRIBES NEW DERIVATIVES OF ACID 1, 3-ALKENOIC DIOXANE FROM FORMULA I WHERE: N IS THE WHOLE 1 OR 2; AND IT IS METHYLENEOXY, VINYLENE OR ETHYLENE; A HIGH 1 IS ALKYLENE (1-6C); R ELEVATED 1 IS A GROUP OF THE FORMULA R (TO THE SQUARE), A (TO THE SQUARE) -, IN WHICH: R (TO THE SQUARE) IS FENILE NOT SUBSTITUTED OR SUPPORTING THREE SUBSTITUTES SELECTED INDEPENDENTLY FROM RENT (1-6C) , ALCOXI (1-6C), ALCANOYL (2-6C). ALQUITIO (1-6C), ALQUILSULFONILO (1-6C), HALOGEN, TRIFLUOROMETILO, NITRO AND CIANO; A (TO THE SQUARE) IS A DIRECT JOINT AR (TO THE SQUARE) OR A GROUP OF THE FORMULA -WC (R HIGH 4) (R HIGH 5) TA AR (TO SQUARE) YR HIGH 4 AND R HIGH 5 ARE INDEPENDENTLY RENT (1- 4C); Q IS A SELECTED HETERO-CYCLE GROUP OF TIAZOL-5-IL AND IMIDAZOL-5-IL, THE LAST ONE BEING NOT SUBSTITUTED OR SUPPORTING AN ALKYL GROUP (1-12C) IN POSITION-1 OF THE IMIDIAZOLA RING; AND R ELEVATED 3 IS HYDROXY, A PHYSIOLOGICALLY ACCEPTABLE ALCOHOL WASTE, OR ALCANOSULFONAMIDE (1-4C); OR ONE OF ITS PHARMACEUTICALLY ACCEPTABLE SALTS. THE COMPOUNDS ARE ANTAGONISTS TO SUB 2 OF TROMBOXANE AND SYNTHESA INHIBITORS TO SUB 2 TROMBOXANE, AND ARE USEFUL FOR THE TREATMENT OF A VARIETY OF DISEASES IN WHICH TROMBOXAN IS DISCUSSED IN SUB 2, SUCH AS CORAZON ISERM DISEASES VASCULAR AND PERIPHERAL VASCULAR DISEASE. THE INVENTION ALSO INCLUDES PROCESSES FOR THE MANUFACTURE AND USE OF THE COMPOUNDS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
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