TRANSGENIC NON-HUMAN ANIMALS HAVING TARGETED LYMPHOCYTE TRANSDUCTION GENES.

摘要

The invention provides transgenic non-human animals and transgenic non-human mammalian cells having at least one functionally disrupted lymphocyte transduction locus, particularly a CD4 locus, targeting constructs used to produce such transgenic stem cells and animals, methods and targeting constructs for inactivating or suppressing expression of endogenous lymphocyte transduction gene loci, transgenes encoding heterologous lymphocyte transduction proteins, and non-human animals that express a human lymphocyte transduction protein and lack expression of a cognate murine lymphocyte transduction protein.