METHOD FOR IDENTIFYING PROTECTIVE ANTIGENS FOR ELICITING NEUTRALIZING ANTIBODIES

摘要

The present invention provides a novel method for the identification of antigens which may be useful for inducing neutralizing antibodies. The method is based on the use of antigens as solid phase capture reagents to bind to a population of antibodies from a subject having an infection and high neutralizing serum titers through the period of natural infection. The method is particularly suited for screening libraries of cloned antibodies, such as phage display combinatorial antibodies.