Protective Antigen (PA) and Toxin Neutralization (TNA) Antibody Patterns in Anthrax Vaccinees Undergoing Serial Plasmapheresis

摘要

Recipients of licensed anthrax vaccine (AVA, Biothrax) could serve as a source of hyperimmune plasma and immunoglobulin for therapy and prophylaxis. We examined serum antibody patterns during serial weekly to biweekly plasmapheresis in 38 individuals previously vaccinated with 4-27 doses of AVA. Immunoglobin G (IgG) to protective antigen (PA) and toxin neutralization assay (TNA) antibody levels were highly correlated with (r = 0.86930) and P.