Cells were co-transfected type II BMP receptor and the use of BMP protein receptor complex for the screening of bone metabolic activity and by type I BMP receptor

摘要

(57) relates to a method of determining whether it is possible that the compound binds to a BMP receptor kinase protein complex, the method [Abstract] The present invention is incorporated in complex samples containing compound Te, and a step of bringing into association a compound of the complex, the complex composed of BMP receptor kinase protein BRK-3 ku type I BMP receptor kinase protein. Relates to a method of determining the concentration of BMP receptor ligands contained in clinical samples Moreover, the method incorporates a sample containing a ligand to the BMP receptor kinase protein complex, the invention, BMP receptor kinase ligand and a step of binding to a protein, further, BMP receptor kinase protein complex is comprised of a BMP receptor kinase protein BRK-3 and Metropolitan IBMP receptor kinase protein. The present invention, host cells co-transfected with an expression vector comprising an expression vector comprising a DNA sequence encoding a BMP receptor kinase protein BRK-3 In addition, a DNA sequence encoding a type I BMP receptor kinase protein about. The present invention were co-transfected with an expression vector comprising an expression vector comprising a DNA sequence encoding a soluble type I BMP receptor kinase protein further, a DNA sequence encoding a soluble BMP receptor kinase protein BRK-3 relates to a host cell. The present invention relates to a method for determining whether a signal produce a test compound as soon as BMP binding to receptor protein complex further.