MONOCLONAL ANTIBODY, METHOD OF PREPARING A MONOCLONAL ANTIBODY, AND PHARMACEUTICAL COMPOSITION AND A DIAGNOSTIC REAGENT COMPRISING THE MONOCLONAL ANTIBODY

摘要

The present invention relates to a method for producing an artificial clonal antibody against a surface antigen, which is directed primarily against a surface surface antigen, which appears to be insignificant in amount to the full amount of antigen injected into a mammal, and which easily loses its in vivo stone feminization. For example, the method of killing according to the invention is applicable to the use of antigenic material from another mammalian species for the grafting of a mammal. The invention further relates to the artificial monoclonal antibody produced by the process of the invention and to a pharmaceutical composition and diagnostic reagent containing such antibodies. The method of the invention is suitable for the production of artificial clonal antibodies against small amounts of cell surface antigen, even if it is unstable from the cell surface antigen staining aspect, and suitable for the detection of parts of the receptor mole specificity. The killing of the present invention is suitable for the production of artificial clonal antibodies in cases in which the presence of other antigens, which are capable of eliciting an immune response, is to be neglected. ŕ