PROCESS FOR THE SYNTHESIS OF SEMI-SYNTHETIC GLYCOSAMINOGLYCANS CONTAINING a-L- GALACTURONIC ACID SUBSTITUTED WITH NUCLEOPHILIC RADICALS IN POSITION 3

摘要

A process for the synthesis of semi-synthetic glycosaminoglycans of general formula III CHEM is described in which one of the saccharide units characteristic of glycosaminoglycans with heparin or heparan structure, more specifically that of alpha -L-iduronic-2-O-sulfate acid, has undergone a structural modification, entirely or in part, with transformation into alpha -L-galacturonic acid substituted in position 3 with nucleophilic radicals of general formula II CHEM Said process is carried out by treating glycosaminoglycans with heparin or heparan structure by means of a nucleophilic reagent in alkaline medium.