Drugs that would benefit from sustained release at a controlled rate for an extended period of time in the stomach or upper intestinal tract are formulated in delivery systems that include a water-swellable particulate matrix impregnated with the drug combined with a chemical agent that pharmacologically induces the fed mode in the patient's stomach. By virtue of this combination, the drug can be ingested independently of the timing of the patient's food intake, and the drug matrix will be retained in the patient's stomach as a continuously dispensing reservoir of the drug even though the particulate matrix as ingested is not large enough to be retained in the patient's stomach other than when the stomach is in the fed mode.
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