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Novel aromatic amines derived from cyclic amines useful as medicines

机译:衍生自环胺的新型芳香胺,可用作药物

摘要

The invention concerns derivatives of formula (I) in which in particular, R1 represents an amino radical selected among one of the substituents (i) to (v): in which R4 and R5 identical or different, represent H or an alkyl radical linear or branched containing 1 to 6 carbon atoms, Q represents O, NH, CH2 or NCH3 and m represents a whole number ranging between 2 and 4; R2 represents H, Cl, OH, OMe, or CH3; X-Y represents N-CH2, N-CH2CH2, CR6-CH2, C=CH; Z1 represents CH2 or CO; Z2 represents O or NH and n represents zero or a whole number ranging between 1 and 6, COR'3 or CHOHR'3, in which R'3 represents an aryl or alkylaryl radical. These compounds are particularly useful as antidepressant drugs.
机译:本发明涉及式(I)的衍生物,其中特别地,R 1代表选自取代基(i)至(v)之一的氨基:其中R 4和R 5相同或不同,代表H或直链或烷基的烷基。含有1至6个碳原子的支链,Q代表O,NH,CH 2或NCH 3,m代表2至4的整数。 R 2代表H,Cl,OH,OMe或CH 3; X-Y代表N-CH 2,N-CH 2 CH 2,CR 6 -CH 2,C = CH; Z1代表CH2或CO; Z 2代表O或NH,n代表0或1至6之间的整数,COR'3或CHOHR'3,其中R'3代表芳基或烷基芳基。这些化合物特别可用作抗抑郁药。

著录项

  • 公开/公告号AU5992298A

    专利类型

  • 公开/公告日1998-08-07

    原文格式PDF

  • 申请/专利权人 PIERRE FABRE MEDICAMENT;

    申请/专利号AU19980059922

  • 发明设计人 MARIE LAMOTHE;SERGE HALAZY;

    申请日1998-01-15

  • 分类号C07D295/20;C07D401/12;A61K31/435;A61K31/495;C07D211/26;C07D211/16;C07D211/64;C07D211/22;

  • 国家 AU

  • 入库时间 2022-08-22 02:53:03

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