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Potassium salt of biphenylmethane derivative and medicine containing the same

机译:联苯甲烷衍生物的钾盐和含有该盐的药物

摘要

The present invention relates to mono or dipotassium 2-ÄÄ5-ethyl-3-Ä2'-(1H-tetrazol-5-yl)biphenyl-4-ylÜmethyl-1,3,4-thiadia zolin-2-ylidenÜaminocarbonylÜ-1-cyclopentenecarboxylate, a pharmaceutical composition containing the compound, use of the compound for pharmaceuticals, and a therapeutic method of circulatory diseases by administering the compound. The mono or dipotassium salt of the compound has a potent angiotensin II antagonist activity and anti-hypertensive effect and also has high bioavailability when administered orally so that it is useful as a pharmaceutical.
机译:本发明涉及2-ÄÄ5-乙基-3-Ä2'-(1H-四唑-5-基)联苯-4-基Ü甲基-1,3,4-噻二唑啉-2-亚胺基氨基羰基-1-环戊烯羧酸单或二钾,含有该化合物的药物组合物,该化合物在药物中的用途以及通过施用该化合物治疗循环系统疾病的方法。该化合物的单钾盐或双钾盐具有有效的血管紧张素II拮抗剂活性和抗高血压作用,并且口服给药时具有高生物利用度,因此可用作药物。

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