OLIGOSACCHARIDES USED FOR INHIBITING THE MITOSIS OF ASTROCYTES AND TUMORAL CELLS OF THE NERVOUS SYSTEM, AND METHODS FOR OBTAINING THEM

摘要

The method for obtaining oligosaccharides starts with the allylation of position (3') of β-lactosides followed by the controlled benzylation which leads to perbenzylated and partially benzylated compounds. The latter are glycosylated in position 3, not benzylated, with a donor of α-L-fucopyranosyl to yield protected trisaccharides. These and perbenzylated β-lactosides are desallylated and, later, are glycosylated with a donator of 2-azido-2-desoxy-α-D-galactopyranosyl to yield protected tetrasaccharides and trisaccharides, respectively. The debenzylation of said products accompanied by the reduction of the azydo group and simultanious acetylation of the amino group produces intermediary products which, by O-desacetylation, leads respectively to the final tetrasaccharides and trisaccharides. The resulting oligosaccharides produce, in vitro, inhibition of the mitosis of astrocytes and tumoral cells of the nervous system and, for this reason, could be used for controlling the glial scar and for the treatment of tumours of the nervous system.