Method for inhibiting angiogenesis using squalamine and squalamine steroid derivatives

摘要

A method of inhibiting angiogenesis in a patient includes administering to the patient an effective amount of squalamine or a pharmaceutically acceptable salt of squalamine. Alternatively, a compound according to the following Formula (III) (or a pharmaceutically acceptable salt thereof) can be administered: ##STR1## wherein Z.sub.5 is -H or -H; each of the substituents Z.sub.7 is selected from the group of --H, --OH, --SH, --NH.sub.2, --F, --(C.sub.1 -C.sub.3)-alkyl, and --(C.sub.1 -C.sub.3)-alkoxy; and one of the substituents Z.sub.12 is - -H and the other is --H or --OH. X' is a polyamine side chain of the formula --X.sub.1 --(CH.sub.2).sub.p --X.sub.2 --(CH.sub.2).sub.q --N(R. sup.II)(R.sup.III), wherein one of X.sub.1 and X.sub.2 is --N(R.sup.IV) and the other is selected from the group of --N(R.sup.V), --O, --S, and -- CH.sub.2. R.sup.IV and R.sup.V are each --H or --(C.sub.1 -C.sub.3)- alkyl, p and q are each an integer of from 0 to 5 (but both are not 0). R. sup. II and R.sup.III in the formula for X' are each --H, --(C.sub.1 -C. sub.3)- alkyl, or --(CH.sub.2).sub.r --N(R.sub.10)(R.sub.11) wherein r is an integer from 2 to 5 and R.sub.10 and R.sub.11 are each --H or --(C.sub. 1 - C.sub.3)-alkyl. R' in Formula (III) is --H or --(C.sub.1 -C.sub.3)- alkyl, and Y' is --(C.sub.1 -C.sub.10)-alkyl, unsubstituted or substituted with - -CO.sub.2 H, --OH, --NH--SO.sub.2 CF.sub.3, --SO.sub.3 H, --PO.sub.3 H. sub.2, --OSO.sub.3 H, --CF.sub.3, --F, ##STR2##