ANTI-VIRAL BENZIMIDAZOLE DERIVATIVES, PREPARATION AND USE THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS

摘要

In the general formula (I) for benzimidazole derivatives, a is 1, 2, 3, 4 or 5, R 0 is hydrogen, halogen, alkyl or alkoxy, hydrogens, halogens, hydroxy, mercapto-cyano, cyano-alkyl, -, nitro, amino, alkylamino, dialkylamino, aza, carboxyl, alkyl, alkenyl, carbamoyl, carbamoyloxy, carbamoylamino, N-alkylcarbamoyl, N, N-dialkylcarbamoyl, alkoxy, alkoxy-carbonyl, alkoxy-carbonyloxy, alkoxy-carbonylamino, trifluoromethoxy, trichloromethoxy, furmyl, alkanoyl, furmyloxy , alkanoyl-oxy, furanyl-amino, alkanoyl-amino, alkylthio, alkylsulfonylphenyl or alkylsulfinyl piperidine, R2 hydrogen atom, amino, alkylcarbonylamino, or alkylsulfonyl -diaro, R3 alkyl, haloalkyl, hydroxyalkyl, optionally substituted cycloalkyl, optionally substituted phenyl, naphthyl, thienyl, thiazolidinyl, optionally substituted thiazole olyl, optionally substituted thiadiazolyl, 5,6-dihydro-4H-1,3-thiazin-2-yl, pyrrolidine, piperidine, or mordant lint, R4 generalized dimethylamino, alkyl- such as haloalkyl, cycloalkyl, optionally substituted phenyl, naphthyl, thienyl, trifluoromethyl, pyrrolidine, piperidine, or lime. Also included within the scope of the invention are pharmaceutically acceptable salts of the above compounds. ŕ