benzimidazole derivatives useful as antiproliferative agents, their preparation processes, pharmaceutical composition comprising the same and uses of said compounds in the preparation of pharmaceutical compositions

摘要

"benzimidazole derivatives useful as antiproliferative agents". the invention relates to compounds of formula 1 and pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein r ^ 1 ^, r ^ 2 ^, r ^ 3 ^, and r ^ 4 ^ are as defined herein. the invention also relates to methods of treating abnormal cell growth, such as cancer, in mammals by administering compounds of formula 1 and to pharmaceutical compositions for treating such disorders containing the compounds of formula 1. the invention also relates to methods of preparing the compounds of formula 1.