NATIVE PROTEIN OF A COMPLEMENT LINE, A FRAGMENT OR VARIANT OF PROTEIN, DNA SEQUENCE CODING A PROTEIN, DNA CONSTRUCT, A CONJUGATE CONTAINING PROTEIN, PHARMACEUTICAL COMPOSITION AND USE OF PROTEIN

摘要

Native complement pathway proteins modified such that the protein is capable of forming a down-regulation resistant C3 convertase. Preferably the modified protein is a modified human C3 protein. DNA sequences encoding such proteins are also provided, together with DNA constructs. Conjugates comprising such proteins and a specific binding moiety, for example an antibody, are also described, as are uses of such proteins and/or conjugates in therapy.