PRION PROPAGATION INHIBITION BY DOMINANT-NEGATIVE PRION PROTEIN MUTANTS

摘要

The present invention relate to a vector which is suitable for gene prophylaxis/gene therapy, containing a nucleic acid fragment coding for a mutated prion protein. The invention further relates to a vaccination agent which contains said vector in addition to the usual auxiliary agents, and to the use of said vector or vaccination agent in the prophylaxis and/or treatment of prion diseases. The invention further relates to non-human mammals e.g., working animals, which are resistant to prion infections.