Inter-subunit contacts in prion oligomers studied by crosslinking of 15N-metabolically labeled prion proteins

摘要

Crosslinking data of the conformational change is in agreement with complementary structural proteomic methods. Limited proteolysis: trypsin and pepsin. HDX: single residue resolution ECD-FTICR. Surface Modification: PCAS pyridine carboxylic acid succinimide (KYST) H_2O_2 labelling (MW).