首页> 外国专利> Methods of producing a beta form of a prion protein, an antibody and a prion protein aggregate, of obtaining a non-aggregated concrete form of a prion protein and a binding agent, of detecting the presence of a non-aggregate in a biological sample. fibrillar and a prion protein, antibodies and a beta form of prion protein or its aggregate in a sample, to identify a substance, to prevent and / or treat a deprived disease, to diagnose a predisposition for the presence of a prion disease and detract from a biological sample, beta form of a prion protein, antibody, hybridoma cell, agent, non-fibrillary aggregate, uses of a binding agent, an aggregate and beta form of a prion protein, kit to diagnose a disease of primary, pharmaceutical composition and vaccine composition

Methods of producing a beta form of a prion protein, an antibody and a prion protein aggregate, of obtaining a non-aggregated concrete form of a prion protein and a binding agent, of detecting the presence of a non-aggregate in a biological sample. fibrillar and a prion protein, antibodies and a beta form of prion protein or its aggregate in a sample, to identify a substance, to prevent and / or treat a deprived disease, to diagnose a predisposition for the presence of a prion disease and detract from a biological sample, beta form of a prion protein, antibody, hybridoma cell, agent, non-fibrillary aggregate, uses of a binding agent, an aggregate and beta form of a prion protein, kit to diagnose a disease of primary, pharmaceutical composition and vaccine composition

机译:产生β形式的病毒蛋白,抗体和a病毒蛋白聚集体的方法,获得非聚集的a病毒蛋白质和结合剂的具体形式,检测生物样品中非聚集体的存在的方法。样品中的原纤维和a病毒蛋白,抗体和a蛋白的β形式或其聚集体,以鉴定物质,预防和/或治疗被剥夺的疾病,诊断存在a病毒疾病的诱因并减少生物样品,beta蛋白的β形式,抗体,杂交瘤细胞,药剂,非原纤维聚集体,结合剂的用途,蛋白的聚集体和β形式,诊断原发疾病的试剂盒,药物组合物和疫苗成分

摘要

"METHODS OF PRODUCING A BETA FORM OF A PRIENE AAPROTEIN, AN ANTIBODY AND A PRIENE PROTEIN AGGREGATE, OF OBTAINING AN AGGREGATE BETTLE FORM A PRIENE PROTECTIN AND A LARGE AGAINSTEATING AGENT, DETECTING A DEGREE OF STEAM DEGREE. -FIBRILLATE EDE A PRIENE PROTEIN, ANTIBODIES AND A BETA FORM OF PRIENE PROTEIN OR ITS AGGREGATE IN A SAMPLE, TO IDENTIFY A AGENT, TO PREVENT AND / OR TREAT A DEPRIENCIAL DISEASE, TO DIAGNOSE A PREDICTIVE DISHESION AND DETRACT A BIOLOGICAL SAMPLE, BETA FORM OF A PRIENOUS ANTIBODY, ANTIBODY, DEHIBRIDOMA CELL, AGENT, NON-FIBRILLATE AGGREGATE, USES OF AN AGGREGATE AGENT AND A AGENT OF A AGE OF A BODY AGAIN PRIENE, PHARMACEUTICAL COMPOSITION AND VACCINE COMPOSITION ". The present invention relates to a method of producing a 225 form of a prion protein which preferably has more leaves- 225 than the helical structure- 244 and is soluble in the absence of a denaturant and / or is non -aggregated and exhibits partial resistance to proteinase K digestion. The invention also relates to the use of forma- 225 in medicine, especially to create antibodies useful in the treatment and / or diagnosis of prion diseases. The invention also relates to methods of screening compounds that are capable of inhibiting and / or reversing the conversion of the 244 form of a prion protein to a 225 form, and to uses of the compounds identified in medicine.
机译:“生产β蛋白形式的蛋白,一种抗体和一种蛋白融合物的方法,要获得一种球蛋白形式的一种蛋白蛋白和一种大的增糖剂,来检测一种程度的STEA,纤维蛋白。以及一种蛋白质形式的贝塔蛋白蛋白或其在样品中的聚集体,以鉴定一种药物,预防和/或治疗一种疾病,诊断出预期的分离并破坏一种生物样品,一种著名的抗体,一种抗体,一种贝塔蛋白细胞,试剂,非原纤维状聚集体,聚集体试剂的使用以及再次使用普林的身体,药物组合物和疫苗组合物的年龄”。本发明涉及产生<病毒蛋白的<225>形式的方法,该which病毒蛋白优选具有比螺旋结构-<244>更多的叶-<225>并且在不存在变性剂的情况下可溶和/或不具有-聚集并显示出对蛋白酶K消化的部分抗性。本发明还涉及formal- <225>在医学中的用途,特别是产生可用于治疗和/或诊断病毒疾病的抗体。本发明还涉及筛选能够抑制和/或逆转a病毒蛋白的<244>形式向<225>形式的转化的化合物的方法,以及在医学中鉴定的化合物的用途。

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