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Prion propagation inhibition by dominant-negative prion protein mutants
Prion propagation inhibition by dominant-negative prion protein mutants
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机译:显性负病毒蛋白突变体对病毒的繁殖抑制
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摘要
The present invention relates to a vector which is suitable for gene prophylaxis/gene therapy, containing a nucleic acid fragment coding for a mutated prion protein. The invention further relates to a vaccination agent which contains the vector in addition to the usual auxiliary agents, and to the use of the vector or vaccination agent in the prophylaxis and/or treatment of prion diseases. The invention further relates to non-human mammals, e.g. working animals, which are resistant to prion infections.
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